Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

BACKGROUND: Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The...

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Bibliografische gegevens
Gepubliceerd in:J Exp Clin Cancer Res
Hoofdauteurs: Mele, Luigi, la Noce, Marcella, Paino, Francesca, Regad, Tarik, Wagner, Sarah, Liccardo, Davide, Papaccio, Gianpaolo, Lombardi, Angela, Caraglia, Michele, Tirino, Virginia, Desiderio, Vincenzo, Papaccio, Federica
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2019
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466760/
https://ncbi.nlm.nih.gov/pubmed/30987650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1164-5
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