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Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding

The activity of microsomal cytochromes P450 (CYP) is strictly dependent on the supply of electrons provided by NADPH cytochrome P450 oxidoreductase (CPR). The variant nature of the isoform-specific proximal interface of microsomal CYPs implies that the interacting interface between the two proteins...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Esteves, Francisco, Urban, Philippe, Rueff, José, Truan, Gilles, Kranendonk, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555755/
https://ncbi.nlm.nih.gov/pubmed/32933097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186669
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