The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength

NADPH-cytochrome P450 reductase (CPR) is a redox partner of microsomal cytochromes P450 and is a prototype of the diflavin reductase family. CPR contains 3 distinct functional domains: a FMN-binding domain (acceptor reduction), a linker (hinge), and a connecting/FAD domain (NADPH oxidation). It has...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Pharmacol
Egile Nagusiak: Campelo, Diana, Lautier, Thomas, Urban, Philippe, Esteves, Francisco, Bozonnet, Sophie, Truan, Gilles, Kranendonk, Michel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2017
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5670117/
https://ncbi.nlm.nih.gov/pubmed/29163152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00755
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