The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners

NADPH cytochrome P450 oxidoreductase (CPR) is the obligatory electron supplier that sustains the activity of microsomal cytochrome P450 (CYP) enzymes. The variant nature of the isoform-specific proximal interface of microsomal CYPs indicates that CPR is capable of multiple degenerated interactions w...

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Udgivet i:Front Pharmacol
Main Authors: Esteves, Francisco, Campelo, Diana, Gomes, Bruno Costa, Urban, Philippe, Bozonnet, Sophie, Lautier, Thomas, Rueff, José, Truan, Gilles, Kranendonk, Michel
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7094780/
https://ncbi.nlm.nih.gov/pubmed/32256365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00299
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