Improvements in the Oral Absorption and Anticancer Efficacy of an Oxaliplatin-Loaded Solid Formulation: Pharmacokinetic Properties in Rats and Nonhuman Primates and the Effects of Oral Metronomic Dosing on Colorectal Cancer

OBJECTIVE: The anticancer efficacy of orally administered chemotherapeutics is often constrained by low intestinal membrane permeability and oral bioavailability. In this context, we designed a solid oral formulation of oxaliplatin (OP), a third-generation cisplatin analog, to improve oral bioavaila...

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Enregistré dans:
Détails bibliographiques
Publié dans:Int J Nanomedicine
Auteurs principaux: Pangeni, Rudra, Subedi, Laxman, Jha, Saurav Kumar, Kweon, Seho, Kang, Seo-Hee, Chang, Kwan-Young, Choi, Jeong Uk, Byun, Youngro, Park, Jin Woo
Format: Artigo
Langue:Inglês
Publié: Dove 2020
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555381/
https://ncbi.nlm.nih.gov/pubmed/33116497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S267424
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