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Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect
OBJECTIVE: The current study sought to design an oral delivery system of pemetrexed (PMX), a multitargeted antifolate antimetabolite, by enhancing its intestinal membrane permeability. MATERIALS AND METHODS: PMX was ionically complexed with a permeation enhancer such as N(α)-deoxycholyl-l-lysyl-meth...
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| Gepubliceerd in: | Int J Nanomedicine |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Dove Medical Press
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5995301/ https://ncbi.nlm.nih.gov/pubmed/29922055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S167958 |
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