Enhanced oral absorption of pemetrexed by ion-pairing complex formation with deoxycholic acid derivative and multiple nanoemulsion formulations: preparation, characterization, and in vivo oral bioavailability and anticancer effect

OBJECTIVE: The current study sought to design an oral delivery system of pemetrexed (PMX), a multitargeted antifolate antimetabolite, by enhancing its intestinal membrane permeability. MATERIALS AND METHODS: PMX was ionically complexed with a permeation enhancer such as N(α)-deoxycholyl-l-lysyl-meth...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Nanomedicine
Hauptverfasser: Pangeni, Rudra, Choi, Jeong Uk, Panthi, Vijay Kumar, Byun, Youngro, Park, Jin Woo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2018
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995301/
https://ncbi.nlm.nih.gov/pubmed/29922055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S167958
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