Intestinal transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating an ion-pairing complex of pemetrexed with deoxycholic acid derivative

OBJECTIVE: The rational combination of immunotherapy with standard chemotherapy shows synergistic clinical activities in cancer treatment. In the present study, an oral powder formulation of pemetrexed (PMX) was developed to enhance intestinal membrane permeability and investigate its application in...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Pangeni, Rudra, Jha, Saurav Kumar, Maharjan, Ruby, Choi, Jeong Uk, Chang, Kwan-Young, Choi, Young Kweon, Byun, Youngro, Park, Jin Woo
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2019
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690926/
https://ncbi.nlm.nih.gov/pubmed/31496690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S209722
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