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Intestinal transport mechanism and in vivo anticancer efficacy of a solid oral formulation incorporating an ion-pairing complex of pemetrexed with deoxycholic acid derivative

OBJECTIVE: The rational combination of immunotherapy with standard chemotherapy shows synergistic clinical activities in cancer treatment. In the present study, an oral powder formulation of pemetrexed (PMX) was developed to enhance intestinal membrane permeability and investigate its application in...

詳細記述

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書誌詳細
出版年:Int J Nanomedicine
主要な著者: Pangeni, Rudra, Jha, Saurav Kumar, Maharjan, Ruby, Choi, Jeong Uk, Chang, Kwan-Young, Choi, Young Kweon, Byun, Youngro, Park, Jin Woo
フォーマット: Artigo
言語:Inglês
出版事項: Dove 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6690926/
https://ncbi.nlm.nih.gov/pubmed/31496690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S209722
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