Improvements in the Oral Absorption and Anticancer Efficacy of an Oxaliplatin-Loaded Solid Formulation: Pharmacokinetic Properties in Rats and Nonhuman Primates and the Effects of Oral Metronomic Dosing on Colorectal Cancer

OBJECTIVE: The anticancer efficacy of orally administered chemotherapeutics is often constrained by low intestinal membrane permeability and oral bioavailability. In this context, we designed a solid oral formulation of oxaliplatin (OP), a third-generation cisplatin analog, to improve oral bioavaila...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Int J Nanomedicine
Autori principali: Pangeni, Rudra, Subedi, Laxman, Jha, Saurav Kumar, Kweon, Seho, Kang, Seo-Hee, Chang, Kwan-Young, Choi, Jeong Uk, Byun, Youngro, Park, Jin Woo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555381/
https://ncbi.nlm.nih.gov/pubmed/33116497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S267424
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi