Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B

APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element mediates repression in normal cells and that expressio...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Roelofs, Pieter A, Goh, Chai Yeen, Chua, Boon Haow, Jarvis, Matthew C, Stewart, Teneale A, McCann, Jennifer L, McDougle, Rebecca M, Carpenter, Michael A, Martens, John WM, Span, Paul N, Kappei, Dennis, Harris, Reuben S
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553775/
https://ncbi.nlm.nih.gov/pubmed/32985974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61287
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