Engineering strategy to improve peptide analogs: from structure-based computational design to tumor homing

We present a chemical strategy to engineer analogs of the tumor-homing peptide CREKA (Cys-Arg-Glu-Lys-Ala), which binds to fibrin and fibrin-associated clotted plasma proteins in tumor vessels (Simberg et al. in Proc Natl Acad Sci USA 104:932–936, 2007) with improved ability to inhibit tumor growth....

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Detalhes bibliográficos
Publicado no:J Comput Aided Mol Des
Main Authors: Zanuy, David, Sayago, Francisco J., Revilla-López, Guillem, Ballano, Gema, Agemy, Lilach, Kotamraju, Venkata Ramana, Jiménez, Ana I., Cativiela, Carlos, Nussinov, Ruth, Sawvel, April M., Stucky, Galen, Ruoslahti, Erkki, Alemán, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553648/
https://ncbi.nlm.nih.gov/pubmed/23239171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-012-9623-5
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