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In silico molecular engineering for a targeted replacement in a tumor-homing peptide

A new amino acid has been designed as a replacement for arginine (Arg, R) to protect the tumor-homing pentapeptide CREKA from proteases. This amino acid, denoted (Pro)hArg, is characterized by a proline skeleton bearing a specifically oriented guanidinium side chain. This residue combines the abilit...

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Detalhes bibliográficos
Main Authors: Zanuy, David, Flores-Ortega, Alejandra, Jiménez, Ana I., Calaza, M. Isabel, Cativiela, Carlos, Nussinov, Ruth, Ruoslahti, Erkki, Alemán, Carlos
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734192/
https://ncbi.nlm.nih.gov/pubmed/19432404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp9006119
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