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In silico molecular engineering for a targeted replacement in a tumor-homing peptide
A new amino acid has been designed as a replacement for arginine (Arg, R) to protect the tumor-homing pentapeptide CREKA from proteases. This amino acid, denoted (Pro)hArg, is characterized by a proline skeleton bearing a specifically oriented guanidinium side chain. This residue combines the abilit...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734192/ https://ncbi.nlm.nih.gov/pubmed/19432404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp9006119 |
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