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Exploring the energy landscape of a molecular engineered analog of a tumor-homing peptide

Recently a new non-coded amino acid was designed as a replacement for Arg, to protect the tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) from proteases. This constrained Arg analog, denoted c(5)Arg, was engineered to also promote the stability of the CREKA bioactive conformation. The conforma...

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Bibliografiske detaljer
Udgivet i:Phys Chem Chem Phys
Main Authors: Revilla-López, Guillem, Torras, Juan, Nussinov, Ruth, Alemán, Carlos, Zanuy, David
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385989/
https://ncbi.nlm.nih.gov/pubmed/21258721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cp02572k
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