Ligand with Two Modes of Interaction with the Dopamine D(2) Receptor–An Induced-Fit Mechanism of Insurmountable Antagonism

[Image: see text] A solid understanding of the mechanisms governing ligand binding is crucial for rational design of therapeutics targeting the dopamine D(2) receptor (D(2)R). Here, we use G protein-coupled inward rectifier potassium (GIRK) channel activation in Xenopus oocytes to measure the kineti...

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Pubblicato in:ACS Chem Neurosci
Autori principali: Ågren, Richard, Zeberg, Hugo, Stępniewski, Tomasz Maciej, Free, R. Benjamin, Reilly, Sean W., Luedtke, Robert R., Århem, Peter, Ciruela, Francisco, Sibley, David R., Mach, Robert H., Selent, Jana, Nilsson, Johanna, Sahlholm, Kristoffer
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553383/
https://ncbi.nlm.nih.gov/pubmed/32865974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.0c00477
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