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The Beta-Arrestin-Biased Dopamine D(2) Receptor Ligand, UNC9994, Is a Partial Agonist at G-Protein-Mediated Potassium Channel Activation
BACKGROUND: Previous evidence suggests that UNC9994 is a beta-arrestin2-selective agonist at the dopamine D(2) receptor, lacking ability both to activate and antagonize G protein-dependent signaling. However, this has only been reported by one laboratory using a single assay. METHODS: We used G prot...
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| 發表在: | Int J Neuropsychopharmacol |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6276031/ https://ncbi.nlm.nih.gov/pubmed/29986044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyy059 |
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