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Closed and open state dependent block of potassium channels cause opposing effects on excitability – a computational approach

Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local anesthetic and antiarrhythmics, is open state-dep...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Ågren, Richard, Nilsson, Johanna, Århem, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546692/
https://ncbi.nlm.nih.gov/pubmed/31160624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44564-x
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