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Closed and open state dependent block of potassium channels cause opposing effects on excitability – a computational approach
Block of voltage-gated potassium (Kv) channels has been demonstrated to affect neuronal activity described as increasing excitability. The effect has been associated with a closed-state dependent block. However, the block of Kv channels in e.g. local anesthetic and antiarrhythmics, is open state-dep...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546692/ https://ncbi.nlm.nih.gov/pubmed/31160624 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-44564-x |
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