P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals

[Image: see text] Herein is reported a novel screening paradigm PURE (P450s under restriction) for the identification and optimization of hits as part of a hepatitis B virus (HBV) antiviral discovery program. To closely represent in vivo hepatocytes, differentiated HepaRG cells (dHRGs) and primary h...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Hartman, George D., Kuduk, Scott D., Espiritu, Christine, Lam, Angela M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2020
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7549254/
https://ncbi.nlm.nih.gov/pubmed/33062174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00630
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki