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P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals
[Image: see text] Herein is reported a novel screening paradigm PURE (P450s under restriction) for the identification and optimization of hits as part of a hepatitis B virus (HBV) antiviral discovery program. To closely represent in vivo hepatocytes, differentiated HepaRG cells (dHRGs) and primary h...
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| Vydáno v: | ACS Med Chem Lett |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2020
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7549254/ https://ncbi.nlm.nih.gov/pubmed/33062174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00630 |
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