Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG)

The canonical mode of action (MOA) of microcystins (MC) is the inhibition of protein phosphatases, but complete characterization of toxicity pathways is lacking. The existence of over 200 MC congeners complicates risk estimates worldwide. This work employed RNA-seq to provide an unbiased and compreh...

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Udgivet i:Toxicon X
Main Authors: Biales, Adam D., Bencic, David C., Flick, Robert W., Delacruz, Armah, Gordon, Denise A., Huang, Weichun
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670210/
https://ncbi.nlm.nih.gov/pubmed/33235993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxcx.2020.100060
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