Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG)

The canonical mode of action (MOA) of microcystins (MC) is the inhibition of protein phosphatases, but complete characterization of toxicity pathways is lacking. The existence of over 200 MC congeners complicates risk estimates worldwide. This work employed RNA-seq to provide an unbiased and compreh...

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Gepubliceerd in:Toxicon X
Hoofdauteurs: Biales, Adam D., Bencic, David C., Flick, Robert W., Delacruz, Armah, Gordon, Denise A., Huang, Weichun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670210/
https://ncbi.nlm.nih.gov/pubmed/33235993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxcx.2020.100060
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