Global transcriptomic profiling of microcystin-LR or -RR treated hepatocytes (HepaRG)

The canonical mode of action (MOA) of microcystins (MC) is the inhibition of protein phosphatases, but complete characterization of toxicity pathways is lacking. The existence of over 200 MC congeners complicates risk estimates worldwide. This work employed RNA-seq to provide an unbiased and compreh...

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Publicado en:Toxicon X
Autores principales: Biales, Adam D., Bencic, David C., Flick, Robert W., Delacruz, Armah, Gordon, Denise A., Huang, Weichun
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7670210/
https://ncbi.nlm.nih.gov/pubmed/33235993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxcx.2020.100060
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