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Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition
Concentration/dose addition is widely used for compounds that act by similar mechanisms. But it cannot make predictions for mixtures of full and partial agonists for effect levels above that of the least efficacious component. As partial agonists are common, we developed generalized concentration ad...
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| Publicado en: | Toxicol Sci |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7548291/ https://ncbi.nlm.nih.gov/pubmed/32726424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa108 |
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