Application of Generalized Concentration Addition to Predict Mixture Effects of Glucocorticoid Receptor Ligands

Environmental exposures often occur in complex mixtures and at low concentrations. Generalized concentration addition (GCA) is a method used to estimate the joint effect of receptor ligands that vary in efficacy. GCA models have been successfully applied to mixtures of aryl hydrocarbon receptor (AhR...

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Bibliographic Details
Published in:Toxicol In Vitro
Main Authors: de la Rosa, Rosemarie, Schlezinger, Jennifer J., Smith, Martyn T., Webster, Thomas F.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594746/
https://ncbi.nlm.nih.gov/pubmed/32858110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2020.104975
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