Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists

BACKGROUND: Predicting the expected outcome of a combination exposure is critical to risk assessment. The toxic equivalency factor (TEF) approach used for analyzing joint effects of dioxin-like chemicals is a special case of the method of concentration addition. However, the TEF method assumes that...

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Auteurs principaux: Howard, Gregory J., Schlezinger, Jennifer J., Hahn, Mark E., Webster, Thomas F.
Format: Artigo
Langue:Inglês
Publié: National Institute of Environmental Health Sciences 2010
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866683/
https://ncbi.nlm.nih.gov/pubmed/20435555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0901312
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