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Computational generation of an annotated gigalibrary of synthesizable, composite peptidic macrocycles
Peptidomimetic macrocycles have the potential to regulate challenging therapeutic targets. Structures of this type having precise shapes and drug-like character are particularly coveted, but are relatively difficult to synthesize. Our laboratory has developed robust methods that integrate small-pept...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7547232/ https://ncbi.nlm.nih.gov/pubmed/32948694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007304117 |
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