Dexamethasone rescues TGF-β1-mediated β(2)-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells

Glucocorticoids (GCs) and β(2)-adrenergic receptor (β(2)AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression in human airway smooth muscle (HASM), thereby attenuating airway inflammation and airway hyperresponsiveness that define asthma. Our previous studies showe...

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Udgivet i:Respir Res
Main Authors: Chung, Elena, Ojiaku, Christie A., Cao, Gaoyuan, Parikh, Vishal, Deeney, Brian, Xu, Shengjie, Wang, Serena, Panettieri, Reynold A., Koziol-White, Cynthia
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545943/
https://ncbi.nlm.nih.gov/pubmed/33032603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-020-01522-w
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