Dexamethasone rescues TGF-β1-mediated β(2)-adrenergic receptor dysfunction and attenuates phosphodiesterase 4D expression in human airway smooth muscle cells

Glucocorticoids (GCs) and β(2)-adrenergic receptor (β(2)AR) agonists improve asthma outcomes in most patients. GCs also modulate gene expression in human airway smooth muscle (HASM), thereby attenuating airway inflammation and airway hyperresponsiveness that define asthma. Our previous studies showe...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Respir Res
Auteurs principaux: Chung, Elena, Ojiaku, Christie A., Cao, Gaoyuan, Parikh, Vishal, Deeney, Brian, Xu, Shengjie, Wang, Serena, Panettieri, Reynold A., Koziol-White, Cynthia
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545943/
https://ncbi.nlm.nih.gov/pubmed/33032603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-020-01522-w
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires