TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis

Recently, bitter taste receptors (TAS2Rs) were found in the lung and act to relax airway smooth muscle (ASM) via intracellular Ca(2+) concentration signaling generated from restricted phospholipase C activation. As potential therapy, TAS2R agonists could be add-on treatment when patients fail to ach...

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Main Authors: An, Steven S., Wang, Wayne C. H., Koziol-White, Cynthia J., Ahn, Kwangmi, Lee, Danielle Y., Kurten, Richard C., Panettieri, Reynold A., Liggett, Stephen B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3423830/
https://ncbi.nlm.nih.gov/pubmed/22683571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00126.2012
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