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Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal–regulated Kinase 1/2
Bitter taste receptor (TAS2R) agonists dilate airways by receptor-dependent smooth muscle relaxation. Besides their coupling to relaxation, we have found that human airway smooth muscle (HASM) cell TAS2Rs activate (phosphorylate) extracellular signal–related kinase 1/2 (ERK1/2), but the cellular eff...
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| Опубликовано в: : | Am J Respir Cell Mol Biol |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Thoracic Society
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503617/ https://ncbi.nlm.nih.gov/pubmed/30365340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2018-0189OC |
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