Biased TAS2R Bronchodilators Inhibit Airway Smooth Muscle Growth by Downregulating Phosphorylated Extracellular Signal–regulated Kinase 1/2

Bitter taste receptor (TAS2R) agonists dilate airways by receptor-dependent smooth muscle relaxation. Besides their coupling to relaxation, we have found that human airway smooth muscle (HASM) cell TAS2Rs activate (phosphorylate) extracellular signal–related kinase 1/2 (ERK1/2), but the cellular eff...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Am J Respir Cell Mol Biol
Auteurs principaux: Kim, Donghwa, Cho, Soomin, Castaño, Maria A., Panettieri, Reynold A., Woo, Jung A., Liggett, Stephen B.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2019
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503617/
https://ncbi.nlm.nih.gov/pubmed/30365340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2018-0189OC
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires