Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma

β(2)-adrenergic receptor (β(2)AR) agonists (β(2)-agonist) are the most commonly used therapy for acute relief in asthma, but chronic use of these bronchodilators paradoxically exacerbates airway hyper-responsiveness. Activation of βARs by β-agonist leads to desensitization (inactivation) by phosphor...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Gupta, Manveen K., Asosingh, Kewal, Aronica, Mark, Comhair, Suzy, Cao, Gaoyuan, Erzurum, Serpil, Panettieri, Reynold A., Naga Prasad, Sathyamangla V.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4449172/
https://ncbi.nlm.nih.gov/pubmed/26023787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0125803
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker