Interdependence of hypoxia and β-adrenergic receptor signaling in pulmonary arterial hypertension

The β-adrenergic receptor (βAR) exists in an equilibrium of inactive and active conformational states, which shifts in response to different ligands and results in downstream signaling. In addition to cAMP, βAR signals to hypoxia-inducible factor 1 (HIF-1). We hypothesized that a βAR-active conforma...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Stephens, Olivia R., Weiss, Kelly, Frimel, Matthew, Rose, Jonathan A., Sun, Yu, Asosingh, Kewal, Farha, Samar, Highland, Kristin B., Prasad, Sathyamangla V. Naga, Erzurum, Serpil C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766716/
https://ncbi.nlm.nih.gov/pubmed/31242023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00015.2019
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