Interdependence of hypoxia and β-adrenergic receptor signaling in pulmonary arterial hypertension

The β-adrenergic receptor (βAR) exists in an equilibrium of inactive and active conformational states, which shifts in response to different ligands and results in downstream signaling. In addition to cAMP, βAR signals to hypoxia-inducible factor 1 (HIF-1). We hypothesized that a βAR-active conforma...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Am J Physiol Lung Cell Mol Physiol
Päätekijät: Stephens, Olivia R., Weiss, Kelly, Frimel, Matthew, Rose, Jonathan A., Sun, Yu, Asosingh, Kewal, Farha, Samar, Highland, Kristin B., Prasad, Sathyamangla V. Naga, Erzurum, Serpil C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Physiological Society 2019
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766716/
https://ncbi.nlm.nih.gov/pubmed/31242023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00015.2019
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