TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3

Transforming growth factor β1 (TGF-β1), a cytokine whose levels are elevated in the airways of patients with asthma, perpetuates airway inflammation and modulates airway structural cell remodeling. However, the role of TGF-β1 in excessive airway narrowing in asthma, or airway hyperresponsiveness (AH...

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Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Ojiaku, Christie A., Cao, Gaoyuan, Zhu, Wanqu, Yoo, Edwin J., Shumyatcher, Maya, Himes, Blanca E., An, Steven S., Panettieri, Reynold A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2018
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946330/
https://ncbi.nlm.nih.gov/pubmed/28984468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0247OC
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