Periphilin self-association underpins epigenetic silencing by the HUSH complex

Transcription of integrated DNA from viruses or transposable elements is tightly regulated to prevent pathogenesis. The Human Silencing Hub (HUSH), composed of Periphilin, TASOR and MPP8, silences transcriptionally active viral and endogenous transgenes. HUSH recruits effectors that alter the epigen...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Prigozhin, Daniil M, Douse, Christopher H, Farleigh, Laura E, Albecka, Anna, Tchasovnikarova, Iva A, Timms, Richard T, Oda, Shun-ichiro, Adolf, Frank, Freund, Stefan M V, Maslen, Sarah, Lehner, Paul J, Modis, Yorgo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544229/
https://ncbi.nlm.nih.gov/pubmed/32976585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa785
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