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Hyper-activation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2
Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot-Marie-Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood. Here, through a genome-wide CRISPR/Cas9-mediated forward genetic screen, we identify MORC2 as an essential gene required for epige...
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| Publicado en: | Nat Genet |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5493197/ https://ncbi.nlm.nih.gov/pubmed/28581500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3878 |
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