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Hyper-activation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2

Dominant mutations in the MORC2 gene have recently been shown to cause axonal Charcot-Marie-Tooth (CMT) disease, but the cellular function of MORC2 is poorly understood. Here, through a genome-wide CRISPR/Cas9-mediated forward genetic screen, we identify MORC2 as an essential gene required for epige...

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Publicado en:Nat Genet
Main Authors: Tchasovnikarova, Iva A., Timms, Richard T., Douse, Christopher H., Roberts, Rhys C., Dougan, Gordon, Kingston, Robert E., Modis, Yorgo, Lehner, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5493197/
https://ncbi.nlm.nih.gov/pubmed/28581500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3878
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