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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control
The HUSH complex represses retroviruses, transposons and genes to maintain the integrity of vertebrate genomes. HUSH regulates deposition of the epigenetic mark H3K9me3, but how its three core subunits — TASOR, MPP8 and Periphilin — contribute to assembly and targeting of the complex remains unknown...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7532188/ https://ncbi.nlm.nih.gov/pubmed/33009411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18761-6 |
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