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Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells
Forward genetic screens in Drosophila melanogaster for modifiers of position-effect variegation have revealed the basis of much of our understanding of heterochromatin. We took an analogous approach to identify genes required for epigenetic repression in human cells. A non-lethal forward genetic scr...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4487827/ https://ncbi.nlm.nih.gov/pubmed/26022416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa7227 |
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