Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair mechanisms that modulate this process and gover...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Tumurkhuu, Gantsetseg, Chen, Shuang, Montano, Erica N., Ercan Laguna, Duygu, De Los Santos, Gabriela, Yu, Jeong Min, Lane, Malcolm, Yamashita, Michifumi, Markman, Janet L., Blanco, Luz P., Kaplan, Mariana J., Shimada, Kenichi, Crother, Timothy R., Ishimori, Mariko, Wallace, Daniel J., Jefferies, Caroline A., Arditi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541920/
https://ncbi.nlm.nih.gov/pubmed/33072095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.554725
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