Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice

In the Ldlr(-/-) mouse model of atherosclerosis, female Nlrp3(-/-) bone marrow chimera and Nlrp3(-/-) mice developed significantly smaller lesions in the aortic sinus and decreased lipid content in aorta en face, but a similar protection was not observed in males. Ovariectomized female mice lost pro...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Chen, Shuang, Markman, Janet L., Shimada, Kenichi, Crother, Timothy R., Lane, Malcolm, Abolhesn, Amanda, Shah, Prediman K., Arditi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315187/
https://ncbi.nlm.nih.gov/pubmed/32613145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2020.03.016
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