Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome During Apoptosis

We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of interleukin-1β (IL-1β). NLRP3 secondary signal activators such as ATP induced mitochondrial dysfunction and apoptosis, resulting in release of oxi...

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Détails bibliographiques
Auteurs principaux: Shimada, Kenichi, Crother, Timothy R., Karlin, Justin, Dagvadorj, Jargalsaikhan, Chiba, Norika, Chen, Shuang, Ramanujan, V. Krishnan, Wolf, Andrea J., Vergnes, Laurent, Ojcius, David M., Rentsendorj, Altan, Vargas, Mario, Guerrero, Candace, Wang, Yinsheng, Fitzgerald, Katherine A., Underhill, David M., Town, Terrence, Arditi, Moshe
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312986/
https://ncbi.nlm.nih.gov/pubmed/22342844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.01.009
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