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Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome During Apoptosis
We report that in the presence of signal 1 (NF-κB), the NLRP3 inflammasome was activated by mitochondrial apoptotic signaling that licensed production of interleukin-1β (IL-1β). NLRP3 secondary signal activators such as ATP induced mitochondrial dysfunction and apoptosis, resulting in release of oxi...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3312986/ https://ncbi.nlm.nih.gov/pubmed/22342844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.01.009 |
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