Caspase-1 Dependent IL-1β Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection

Chlamydia pneumoniae (CP) is an important human pathogen that causes atypical pneumonia and is associated with various chronic inflammatory disorders. Caspase-1 is a key component of the ‘inflammasome’, and is required to cleave pro-IL-1β to bioactive IL-1β. Here we demonstrate for the first time a...

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Detalhes bibliográficos
Main Authors: Shimada, Kenichi, Crother, Timothy R., Karlin, Justin, Chen, Shuang, Chiba, Norika, Ramanujan, V. Krishnan, Vergnes, Laurent, Ojcius, David M., Arditi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121765/
https://ncbi.nlm.nih.gov/pubmed/21731762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021477
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