The NLRP3 Inflammasome Is Required for the Development of Hypoxemia in LPS/Mechanical Ventilation Acute Lung Injury

IL-1β is a potent proinflammatory cytokine that is implicated in the pathogenesis of acute respiratory distress syndrome. We hypothesized that LPS and mechanical ventilation (MV) together could lead to IL-1β secretion and the development of acute lung injury (ALI), and that this process would be dep...

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Bibliographic Details
Main Authors: Jones, Heather D., Crother, Timothy R., Gonzalez-Villalobos, Romer A., Jupelli, Madhulika, Chen, Shuang, Dagvadorj, Jargalsaikhan, Arditi, Moshe, Shimada, Kenichi
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2014
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3930947/
https://ncbi.nlm.nih.gov/pubmed/24007300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2013-0087OC
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