Alternatively spliced myeloid differentiation protein-2 (MD-2s) protein inhibits TLR4-mediated lung inflammation

We previously identified a novel alternatively spliced isoform of human myeloid differentiation protein-2 (MD-2s) that competitively inhibits binding of MD-2 to TLR4 in vitro. Here we investigated the protective role of MD-2s in LPS-induced acute lung injury by delivering intracheally (i.t.) an aden...

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Publicado no:J Immunol
Main Authors: Tumurkhuu, Gantsetseg, Dagvadorj, Jargalsaikhan, Jones, Heather D., Chen, Shuang, Shimada, Kenichi, Crother, Timothy R., Arditi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323992/
https://ncbi.nlm.nih.gov/pubmed/25576596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402123
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