Chlamydia pneumoniae hijacks a host auto-regulatory IL-1β loop to drive foam cell formation and accelerate atherosclerosis

Pathogen burden accelerate atherosclerosis, but the mechanisms remain unresolved. Activation of the NLRP3 inflammasome is linked to atherogenesis. Here we investigated whether Chlamydia pneumoniae (C.pn) infection engages NLRP3 in promoting atherosclerosis. C.pn potentiated hyperlipidemia-induced in...

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Bibliografiske detaljer
Udgivet i:Cell Metab
Main Authors: Tumurkhuu, Gantsetseg, Dagvadorj, Jargalsaikhan, Porritt, Rebecca A., Crother, Timothy R., Shimada, Kenichi, Tarling, Elizabeth J., Erbay, Ebru, Arditi, Moshe, Chen, Shuang
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125162/
https://ncbi.nlm.nih.gov/pubmed/29937375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.05.027
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