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Lipopolysaccharide induces alveolar macrophage necrosis via CD14 and the P2x7 receptor leading to Interleukin-1α release

Acute lung injury (ALI) remains a serious health issue with little improvement in our understanding of the pathophysiology and therapeutic approaches. We investigated the mechanism that lipopolysaccharide (LPS) induces early neutrophil recruitment to lungs and increases pulmonary vascular permeabili...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Dagvadorj, Jargalsaikhan, Shimada, Kenichi, Chen, Shuang, Jones, Heather D., Tumurkhuu, Gantsetseg, Zhang, Wenxuan, Wawrowsky, Kolja A., Crother, Timothy R., Arditi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423803/
https://ncbi.nlm.nih.gov/pubmed/25862090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.03.007
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