Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice

Cervical cancer (CC) is usually initiated by infection with high‐risk types of human papillomavirus (HPV). The HPV E6 and E7 proteins target p53 and RB, respectively, but other cellular targets likely exist. We generated uterus‐specific MOB1A/B double KO (uMob1DKO) mice, which immediately developed...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Sci
Auteurs principaux: Nishio, Miki, To, Yoko, Maehama, Tomohiko, Aono, Yukari, Otani, Junji, Hikasa, Hiroki, Kitagawa, Akihiro, Mimori, Koshi, Sasaki, Takehiko, Nishina, Hiroshi, Toyokuni, Shinya, Lydon, John P., Nakao, Kazuwa, Wah Mak, Tak, Kiyono, Tohru, Katabuchi, Hidetaka, Tashiro, Hironori, Suzuki, Akira
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Carcinogenesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541006/
https://ncbi.nlm.nih.gov/pubmed/32716083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14581
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