Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice

Cervical cancer (CC) is usually initiated by infection with high‐risk types of human papillomavirus (HPV). The HPV E6 and E7 proteins target p53 and RB, respectively, but other cellular targets likely exist. We generated uterus‐specific MOB1A/B double KO (uMob1DKO) mice, which immediately developed...

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Dettagli Bibliografici
Pubblicato in:Cancer Sci
Autori principali: Nishio, Miki, To, Yoko, Maehama, Tomohiko, Aono, Yukari, Otani, Junji, Hikasa, Hiroki, Kitagawa, Akihiro, Mimori, Koshi, Sasaki, Takehiko, Nishina, Hiroshi, Toyokuni, Shinya, Lydon, John P., Nakao, Kazuwa, Wah Mak, Tak, Kiyono, Tohru, Katabuchi, Hidetaka, Tashiro, Hironori, Suzuki, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Carcinogenesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541006/
https://ncbi.nlm.nih.gov/pubmed/32716083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14581
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