Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice

Mps One Binder Kinase Activator (MOB)1A/1B are core components of the Hippo pathway that coactivate large tumor suppressor homolog (LATS) kinases. Mob1a/1b double deficiency in mouse liver (LMob1DKO) results in hyperplasia of oval cells and immature cholangiocytes accompanied by inflammatory cell in...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nishio, Miki, Sugimachi, Keishi, Goto, Hiroki, Wang, Jia, Morikawa, Takumi, Miyachi, Yosuke, Takano, Yusuke, Hikasa, Hiroki, Itoh, Tohru, Suzuki, Satoshi O., Kurihara, Hiroki, Aishima, Shinichi, Leask, Andrew, Sasaki, Takehiko, Nakano, Toru, Nishina, Hiroshi, Nishikawa, Yuji, Sekido, Yoshitaka, Nakao, Kazuwa, Shin-ya, Kazuo, Mimori, Koshi, Suzuki, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711826/
https://ncbi.nlm.nih.gov/pubmed/26699479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517188113
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