Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

Mps one binder 1a (MOB1A) and MOB1B are key components of the Hippo signaling pathway and are mutated or inactivated in many human cancers. Here we show that intact Mob1a or Mob1b is essential for murine embryogenesis and that loss of the remaining WT Mob1 allele in Mob1a(Δ/Δ)1b(tr/+) or Mob1a(Δ/+)1...

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Main Authors: Nishio, Miki, Hamada, Koichi, Kawahara, Kohichi, Sasaki, Masato, Noguchi, Fumihito, Chiba, Shuhei, Mizuno, Kensaku, Suzuki, Satoshi O., Dong, Youyi, Tokuda, Masaaki, Morikawa, Takumi, Hikasa, Hiroki, Eggenschwiler, Jonathan, Yabuta, Norikazu, Nojima, Hiroshi, Nakagawa, Kentaro, Hata, Yutaka, Nishina, Hiroshi, Mimori, Koshi, Mori, Masaki, Sasaki, Takehiko, Mak, Tak W., Nakano, Toru, Itami, Satoshi, Suzuki, Akira
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533542/
https://ncbi.nlm.nih.gov/pubmed/23143302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63735
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