Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice

Cervical cancer (CC) is usually initiated by infection with high‐risk types of human papillomavirus (HPV). The HPV E6 and E7 proteins target p53 and RB, respectively, but other cellular targets likely exist. We generated uterus‐specific MOB1A/B double KO (uMob1DKO) mice, which immediately developed...

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Veröffentlicht in:Cancer Sci
Hauptverfasser: Nishio, Miki, To, Yoko, Maehama, Tomohiko, Aono, Yukari, Otani, Junji, Hikasa, Hiroki, Kitagawa, Akihiro, Mimori, Koshi, Sasaki, Takehiko, Nishina, Hiroshi, Toyokuni, Shinya, Lydon, John P., Nakao, Kazuwa, Wah Mak, Tak, Kiyono, Tohru, Katabuchi, Hidetaka, Tashiro, Hironori, Suzuki, Akira
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
Schlagworte:
Carcinogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541006/
https://ncbi.nlm.nih.gov/pubmed/32716083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14581
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